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Wil Holtz, Ph.D.


St. Louis
314 552 6512 direct
314 667 3633 fax

Wil has a PhD in cellular and molecular biology and experience as research scientist working for a major biotechnology company.

As a doctoral candidate, he studied molecular mechanisms of cell death in a model of Parkinson's disease. He now assists clients seeking patent protection for biotechnology and pharmaceutical innovations. Having earned both his JD and PhD from Washington University, Wil has developed a deep understanding of the needs, goals, and concerns of his clients, and has the scientific foundation to understand the complex nature of their work as well as their legal issues.

Wil has published in peer reviewed scientific journals such as Journal of Biological Chemistry, Journal of Neurochemistry, Neurobiology of Disease, and Antioxidants & Redox Signaling. He uses his extensive experience in molecular cloning, DNA and RNA purification, cell culture, immunohistochemistry, protein expression, protein purification, quantitative PCR, gene array analysis, and microscopy in the preparation and prosecution of biotechnology and pharmaceutical patent applications.


"Oxidative Stress-Triggered Unfolded Protein Response is Upstream of Intrinsic Cell Death Evoked by Parkinsonian Mimetics"; Holtz WA, Turetzky JM, Jong YJ, O'Malley KL,
J Neurochem.; 99(1):54-69, 2006 Oct

"Microarray Expression Profiling Identifies Early Signaling Transcripts Associated with 6-OHDA-Induced Dopaminergic Cell Death"; Holtz WA, Turetzky JM, O'Malley KL,
Antioxid Redox Signal.; 7(5-6):639-48, 2005 May-Jun

"Parkinsonian Mimetics Induce Aspects of Unfolded Protein Response in Death of Dopaminergic Neurons"; Holtz WA, O'Malley KL,
J Biol Chem. 2003 May 23;278(21):19367-77, Epub 2003 Feb 21

"Role of Oxidative Stress and the Unfolded Protein Response in 6-OHDA-Mediated Dopaminergic Cell Death"; Program No. 451.4, Holtz WA, O’Malley KL,
2003 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience. Online, 2003